CBMS Lecture Series – Michael Ragusa, Dartmouth College

Date: 2022/05/18
Time: 1:30 pm
Location: Online - 13:30 (EDT)
Lecture | Virtual event

Two Stories of Degradation – Investigating the Initiation of Selective Autophagy in Yeast

Autophagy is a cellular degradation process in which cytosolic material is captured in double membrane vesicles and targeted to lysosomes in mammalian cells or the vacuole in yeast for degradation. One cargo that can be degraded by autophagy is mitochondria. The degradation of mitochondria by autophagy requires the organization of many soluble proteins on the surface of mitochondria to generate distinct initiation sites for this process. We have been utilizing a combination of biochemistry, cell biology and structural biology to investigate how these initiation sites are organized and how these initiation sites recruit membrane.