PhD positions for doctoral School programme in biomedical sciences

Website Synchrotron SOLARIS

We are happy to announce that the Jagiellonian University have opened registration for applicants to the Doctoral School Programme in Biomedical Sciences. The programme is supported by the Jagiellonian Centre for Experimental Therapeutics (JCET), the Malopolska Centre of Biotechnology (MCB) and the SOLARIS National Synchrotron Radiation Centre (SOLARIS). The end of registration is 8.06.2021. The Solaris Centre offers two Ph.D. positions and four research topics.

We are seeking applications from exceptional students to our Ph.D. Programme which will be offering Ph.D studies in the following fields:

Solaris:

The Solaris Centre offers two Ph.D. positions and four following research topics:

1. Project title: High-pressure studies of the structure of selected proteins in crystal and solution

Prof. dr hab. Maciej Kozak/dr inż. Joanna Sławek

Project description: The stability of the 3D structure of proteins under extreme conditions (high pressures, high temperatures, extreme pH or ionic strength values, etc.) is still one of the current problems in fundamental research. The stability of the structure of protein complexes, oligomeric or monomeric proteins at high pressures is also of great importance in their industrial use. On the other hand, understanding the processes related to local structural disorder (e.g. changes in secondary structure) as well as long-range changes (dissociation of oligomeric structures or even complete unfolding of the tertiary structure) induced by pressure is important for understanding these phenomena in a broader (fundamental) context. It is particularly interesting to link these changes, induced by high pressure, with ranges of enzymatic activity or mechanisms of the misfolding of protein structures associated with neurodegenerative diseases. The aim of this project is to investigate the influence of high pressure (even up to 2 GPa) on the spatial structure of model proteins.

2. Project title: Development of GI-SAXS stage for SOLCRYS beamline and studies of model lipid-metal nanoparticle systems using SAXS and XAS

Prof. dr hab. Maciej Kozak/ dr inż. Tomasz Kołodziej

Project description: Metallic nanoparticles are currently widely used in biology and medicine as components of drug delivery systems or bionanosensors, contrast systems in medical imaging or as enhancers in radiotherapy. In order to improve biocompatibility, nanoparticles are integrated into lipid systems (liposomes, multilamellar structures, etc.). However, the incorporation of nanoparticles induces structural changes in the lipid matrix. The aim of this project is to investigate the structure and organization of lipid-metal nanoparticle systems, deposited on selected substrates, using GI-SAXS and analysis of interactions between metal core and lipid bilayers using a combination of SAXS, XAS, and complementary methods.

3. Project title: Neural Networks for cancer detection based on chemical imaging

dr hab. Tomasz P. Wrobel

Project description: This project focuses on the development of proper Neural Networks with IR imaging as a tool for cancer understanding and diagnosis of cancer. The aim is to create label-free, non-destructive, and highly accurate comprehensive histopathological models of pancreatic and breast cancers. IR imaging at the tissue level offers a wealth of information and proper processing is crucial for creating robust classification models, which can be relevant for the clinician. The specific goals will include FT-IR data acquisition on the newly built SOLAIR beamline, creation of Neural Networks models, and optimization in terms of accuracy vs. robustness.

4. Project title: Nanoscale chemical imaging of selected biomedical samples

dr hab. Tomasz P. Wrobel

Project description: This project focuses on creating appropriate experimental approaches for biomedical sample preparation and measurements in the nanoscale. AFM-based IR imaging is a new sub-field of IR imaging and presents new challenges for single cells or biomaterials characterization. This project will be primarily focused on developing a protocol for sample handling and measurements. Once this is established a series of cell lines representative of civilization diseases will be studied along with the effects of drugs. The specific goals will include AFM-IR data acquisition on the newly built SOLAIR beamline, cell cultures, and data handling.

JCET:​

  • endothelial biomedicine, including experimental pharmacology of endotheli
  • vascular drugs metabolism/pharmacokinetics
  • physiology, pathophysiology, biochemistry, analytics,  and biochemical imaging of endothelium.

MCB:

  • bioinformatics
  • developmental biology
  • structural biology
  • chemical imaging
  • microbial genomics
  • cell systems and cell models including stem cells
  • bionanotechnology and bionanochemistry

Successful applicants will then study in at least one of the three excellent and international and interdisciplinary institutes based in Krakow – MCB, JCET or SOLARIS.

The end of registration is 8.06.2021.

How to apply: https://mcb.uj.edu.pl/phd-programme/howtoapply

More information about programme: https://mcb.uj.edu.pl/phd-programme/

See you in Solaris!

To apply for this job please visit synchrotron.uj.edu.pl.