Scientist Cryo-EM

Website BrookhavenLab National Synchrotron Light Source (NSLS-II)

Job ID 2026
Brookhaven National Laboratory is a multipurpose research institution funded primarily by the U.S. Department of Energy’s Office of Science. Located on the center of Long Island, New York, Brookhaven Lab brings world-class facilities and expertise to the most exciting and important questions in basic and applied science—from the birth of our universe to the sustainable energy technology of tomorrow. We operate cutting-edge large-scale facilities for studies in physics, chemistry, biology, medicine, applied science, and a wide range of advanced technologies. The Laboratory’s almost 3,000 scientists, engineers, and support staff are joined each year by more than 4,000 visiting researchers from around the world. Our award-winning history, including seven Nobel Prizes, stretches back to 1947, and we continue to unravel mysteries from the nanoscale to the cosmic scale, and everything in between. Brookhaven is operated and managed by Brookhaven Science Associates, which was founded by the Research Foundation for the State University of New York on behalf of Stony Brook University, and Battelle, a nonprofit applied science and technology organization.

The Laboratory of Biomolecular Structure (LBMS) is a state-of-the-art center for life-science imaging, just coming into operation at Brookhaven National Laboratory. LBMS provides support on single-particle and tomographic cryogenic Transmission Electron Microscopy (TEM) studies (https://www.bnl.gov/cryo-em/). The mission of LBMS is to accelerate dramatically our understanding of processes underlying Biology. The LBMS benefits from a location close to the world-leading X-ray-imaging and structural biology user facilities at National Synchrotron Light Source II (NSLS‑II).

Essential duties:

  • Operate our new cryo-TEMs and ancillary equipment; help develop user programs; communicate with scientific and industrial user communities.
  • Work closely with users; define optimal experimental design on sample preparation and automated data collection.
  • Provide guidance and service in data management and analysis.

Specifically, these scientists will work with the Group Leader to operate the cryo-TEMs and ancillary equipment, perform routine maintenance and quality checks to ensure optimal operation and keep records for user projects and interactions.

Selected candidate will be placed at the appropriate position level dependent upon depth and breadth of relevant knowledge and skills, as well as years of relevant experience.

Requirements:

  • PhD in structural biology or a related field, and at least 3 years of related experience.
  • At least one year of expertise in operating cryo-EM instruments such as Titan Krios, Glacios, Talos L120C, Tecnai TF20.
  • Experience in high-resolution cryo-EM single particle data collection using Leginon or SerialEM, and image processing using Relion, cisTEM, CryoSPARC or EMAN2
  • Experience in cryo-electron tomography data collection using SerialEM or UCSF tomography, and image processing using IMOD, UCSF tomo, or Protomo
  • Cryogenic preparation of biological samples for single-particle or tomography work.
  • Use of cryo-FIB or cryo-microtome to prepare and image cryogenic samples.
  • Experience in negative staining sample preparation and screening.
  • Ability to communicate effectively and diplomatically.
  • Strong organizational skills and methodical record-keeping.

Preferred Knowledge, Skills and Abilities (One or more of the following):

  • Experience in model building using available software such as Phenix and MDFF
  • Experience in model refinement, model evaluation and data deposition
  • Experience in scripting or programming for automation.
  • Experience with fluorescence light microscopy.

Brookhaven National Laboratory and the Energy and Photon Sciences Directorate are committed to your success. We offer a supportive work environment and the resources necessary for you to succeed.

To apply for this job please visit jobs.bnl.gov.