World first for Synchrotron InfraRed Photo-Thermal in Life NanoSciences

Measuring drug-induced molecular changes within a cell at sub-wavelength scale

Synchrotron InfraRed Nanospectroscopy has been used for the first time to measure biomolecular changes induced by a drug (amiodarone) within human cells (macrophages) and localized at 100 nanometre scale, i.e. two orders of magnitude smaller than the IR wavelength used as probe. This was achieved at the Multimode InfraRed Imaging and Micro Spectroscopy (MIRIAM) beamline (B22) at Diamond Light Source, the UK’s national synchrotron facility.

This is a major scientific result in Life Sciences shared by an international team made up of researchers from the School of Cancer and Pharmaceutical Science at Kings College London, the Department of Pharmaceutical Technology and Bio-pharmacy at University of Vienna, and the scientists of the MIRIAM B22 beamline at Diamond.

Read more on the Diamond website

Image: Schematic of Synchrotron photo-thermal IR nano-spectroscopy on mammalian cell at beamline B22.

Protecting chickens from heart disease

The health and welfare of broiler chickens may improve thanks to University of Saskatchewan (USask) researcher Andrew Olkowski and colleagues.

More chickens are raised worldwide than any other livestock animal, so improving their health outcomes would have a big impact.

The broiler chickens that are raised for meat were genetically selected to grow extremely fast, but they often suffer from heart diseases. Heart pump failure is a major health and welfare issue for the broiler chicken industry worldwide. Globally, economic losses associated with heart failure problems in broiler chickens amount to more than $1 billion annually.  

To understand why fast-growing broiler chickens suffer from heart problems, Olkowski and collaborators compared them with their slower-growing broiler counterparts, which have a much lower risk of heart failure, and with Leghorn chickens, which are resistant to heart failure.

Read more on the Canadian Light Source website

Image: University of Saskatchewan researcher Andrew Olkowski. 

Discovery could lead to stronger dental fillings…and less time at the dentist

An international team of researchers used the Canadian Light Source (CLS) at the University of Saskatchewan to discover how to create stronger dental fillings. This is great news for the estimated 96 per cent of Canadians who will have to contend with at least one cavity during their adult lives.

For the first time, an international group of researchers led by Professor Owen Addison from King’s College London has been able to close a gap in the knowledge of photo-activated resin-based composites, commonly used in medical and dental applications.

In a recent paper published in Nature Communications, the team from Alberta, the United Kingdom, Norway and the United States described how they saw inside the resin matrix and gained insight into how filler particles interact with it during setting and influence the dental filling materials.

Read more on the Canadian Light Source website

Image : Prof. Owen Addison (right) with co-author Dr. Dan Romanyk, from the University of Alberta, at the MidIR beamline at the CLS, which they used for their experiment.