Lightsource research on SARS-CoV-2

Lightsource research on SARS-CoV-2

Coronaviruses are a family which includes the common cold, SARS, MERS and the current outbreak of the disease COVID-19, caused by the SARS-CoV-2 virus.
Several facilities of our collaboration have started research about SARS-CoV-2 virus or launched open calls for rapid access. This post will be updated regularly.

Publications on SARS-CoV-2 Rapid Access




Publications

Published articles

2021.12.09 Diamond Light Source (UK) article on their website: Trigger of rare blood clots with AstraZeneca and other COVID vaccines found by scientists

2021.11.06 APS at Argonne National Laboratory (USA) article on their website: Advanced Photon Source Helps Pfizer Create COVID-19 Antiviral Treatment

2021.11.04 ESRF (France) article on their website: EBS X-rays show lung vessels altered by COVID-19 (esrf.fr)

2021.08.11 BESSY II at HZB (Germany) article on their website: HZB coordinates European collaboration to develop active agents against Corona – Helmholtz-Zentrum Berlin (HZB) (helmholtz-berlin.de)

2021.08.10 Canadian Light Source article on their website: Developing antiviral drugs to treat COVID-19 infections

2021.07.06 European XFEL (Germany) article on their website: XFEL: Insights into coronavirus proteins using small angle X-ray scattering

2021.06.21 Diamond Light Source (UK) article on their website: X-ray fluorescence imaging at Diamond helps find a way to improve accuracy of Lateral Flow Tests

2021.06.17 Australian Synchrotron (ANSTO) article on their website: Research finds possible key to long term COVID-19 symptoms

2021.05.11 Swiss Light Source at PSI (Switzerland) article on their website: How remdesivir works against the coronavirus

2021.05.28 SLAC (CA / USA) article from the Stanford Synchrotron Radiation Lightsource (SSRL): Structure-guided Nanobodies Block SARS-CoV-2 Infection | Stanford Synchrotron Radiation Lightsource

2021.05.21 ALS (USA) article on their website: Guiding Target Selection for COVID-19 Antibody Therapeutics

2021.05.21 ESRF (France) article on their website: Combatting COVID-19 with crystallography and cryo-EM (esrf.fr)

2021.05.18 ALS (USA) article on their website: How X-Rays Could Make Reliable, Rapid COVID-19 Tests a Reality | Berkeley Lab (lbl.gov)

2021.04.27 Canadian Light Source (Canada), video on their website Investigating the long-term health impacts of COVID-19 (lightsource.ca)

2021.04.22 Synchrotron Light Research Institute (Thailand), article on their website: SLRI Presented Innovations Against COVID-19 Outbreak to MHESI Minister on His Visit to a Field Hospital at SUT

2021.04.16 Diamond Light Source (UK) article on their website: Massive fragment screen points way to new SARS-CoV-2 inhibitors

2021.04.14 SLAC (CA / USA), article also with news about research at Stanford Synchrotron Radiation Lightsource (SSRL):Researchers search for clues to COVID-19 treatment with help from synchrotron X-rays

2021.04.07 Diamond Light Source (UK), article on their website: First images of cells exposed to COVID-19 vaccine – – Diamond Light Source

2021.04.05 ALS (CA/USA) blog post on Berkeley Lab Biosciences website: New COVID-19 Antibody Supersite Discovered

2021.04.02 PETRA III at DESY (Germany), article and animation on their website DESY X-ray lightsource identifies promising candidate for COVID drugs

2021.03.26 Diamond Light Source (UK), article on their website: New targets for antibodies in the fight against SARS-CoV-2

2021.02.23 Australian Light Source (ANSTO) Australia, article on their website: Progress on understanding what makes COVID-19 more infectious than SARS

2020.12.02 ESRF (France), article and video on their website: ESRF and UCL scientists awarded Chan Zuckerberg Initiative grant for human organ imaging project

2020.11.10 Diamond Light Source (UK), article and video on their website: From nought to sixty in six months… the unmasking of the virus behind COVID-19

2020.10.29 Canadian Light Source (Canada) video on their website: Studying how to damage the COVID-19 virus

2020.10.07 National Synchrotron Light Source II (NSLS-II) at Brookhaven Lab (NY / USA) article on their website: Steady Progress in the Battle Against COVID-19

2020.10.07 Diamond Light Source (UK), article on their website: Structural Biology identifies new information to accelerate structure-based drug design against COVID-19

2020.10.06 MAX IV (Sweden), article on their website: Tackling SARS CoV-2 viral genome replication machinery using X-rays

2020.08.31 SLAC (CA / USA), article also with news about research at Stanford Synchrotron Radiation Lightsource (SSRL): SARS-CoV-2 Spike Protein Targeted for Vaccine

2020.08.27 Diamond Light Source (UK), article on their website: Structural Biology reveals new target to neutralise COVID-19

2020.08.27 Canadian Light Source (Canada) video on their website: Developing more effective drugs

2020.08.25 Australian Synchrotron (ANSTO) (Australia) article on their website: More progress on understanding COVID-19

2020.08.24 DESY (Germany) article on their website: PETRA III provides new insights into COVID-19 lung tissue

2020.08.11 Australian Synchrotron (ANSTO) (Australia) article on their website: Unique immune system of the alpaca being used in COVID-19 research

2020.07.30 Swiss Light Source at PSI (Switzerland) article on their website: COVID-19 research: Anti-viral strategy with double effect

2020.07.29 National Synchrotron Light Source II (NSLS-II) at Brookhaven Lab (NY / USA) article on their website: Ready to join the fight against COVID-19.

2020.07.20 ALBA (Spain) article on their website: A research team from Centro de Investigaciones Biológicas Margarita Salas (CIB-CSIC) uses synchrotron light to study the possible effect of an antitumoral drug of clinical use over the viral cycle of SARS-CoV-2 coronavirus. 

2020.07.15 ALS (USA) article on their website: Antibody from SARS Survivor Neutralizes SARS-CoV-2

2020.07.14 Diamond Light Source (UK), article on their website: Engineered llama antibodies neutralise Covid-19 virus

2020.06.17 European XFEL (Germany) article on their website: Pulling Together: A collaborative research approach to study COVID-19

2020.06.15 European XFEL (Germany) article on their website: Open Science COVID19 analysis platform online

2020.06.09 APS at Argonne National Laboratory (USA) article on their website: Novel Coronavirus Research at the Advanced Photon Source

2020.05. Società Italiana di Fisica publishes an article about research done at Elettra Sincrotrone Trieste (Italy) and the Advanced Light Source (CA / USA): Accelerator facilities support COVID-19-related research

2020.05.27 Diamond Light Source (UK), new animation video demonstrating the work that has been done at Diamond’s XChem facilities.

2020.05.19 Advanced Light Source (CA / USA), article about their latest results: X-ray Experiments Zero in on COVID-19 Antibodies

2020.05.15 Swiss Light Source (Switzerland), article about their first MX results: First MX results of the priority COVID-19 call

2020.05.14 MAX VI (Sweden), article about their research: Tackling SARS CoV-2 viral genome replication machinery using X-rays

2020.05.14 CHESS (NY/USA), article: CHESS to restart in June for COVID-19 research

2020.05.14 the LEAPS initiative brings together many of our European members. The initative published this brochure: Research at LEAPS facilities fighting COVID-19

2020.05.12 Diamond Light Source (UK), article about their collaboration in a consortium: UK consortium launches COVID-19 Protein Portal to provide essential reagents for SARS-CoV-2 research

2020.05.11 Advanced Photon Source (IL/USA), article: Studying Elements from the SARS-CoV-2 Virus at the Bio-CAT Beamline

2020.05.07 European XFEL (Germany), article: European XFEL open for COVID-19 related research

2020.05.06 ESRF (France), article: World X-ray science facilities are contributing to overcoming COVID-19

2020.04.29. BESSY II at HZB (Germany), article: Corona research: Consortium of Berlin research and industry seeks active ingredients

2020.04.29. Swiss Light Source and SwissFEL at PSI (Switzerland), interview series on the PSI website: Research on Covid-19

2020.04.23. PETRA III at DESY (Germany), article: X-ray screening identifies potential candidates for corona drugs

2020.04.21. MAX IV (Sweden), article: BioMAX switches to remote operations in times of COVID-19

2020.04.16. SLAC (CA / USA), article also with news about research at Stanford Synchrotron Radiation Lightsource (SSRL): SLAC joins the global fight against COVID-19

2020.04.15 Berkeley National Lab (CA/ USA), article with a focus on the research at the Advanced Light Source (ALS):
Staff at Berkeley Lab’s X-Ray Facility Mobilize to Support COVID-19-Related Research

2020.04.07 Diamond Light Source (UK), article: Call for Chemists to contribute to the fight against COVID-19
Crowdfunding: COVID-19 Moonshot

2020.04.07. ANSTO’s Australian Synchrotron (Victoria), article: Aiding the global research effort on COVID-19

2020.04.06. National Synchrotron Light Source II (NSLS-II) at Brookhaven Lab (NY / USA), article: Brookhaven Lab Mobilizes Resources in Fight Against COVID-19

2020.04.02. BESSY II at HZB (Germany), article: Corona research: Two days of measuring operation to find the right key

2020.03.31 Diamond Light Source (UK), article: Jointly with Exscientia and Scripps Research, Diamond aims to accelerate the search for drugs to treat COVID-19

2020.03.27 Argonne National Laboratory with the Advanced Photon Source (APS) and other facilities on-site (IL / USA), article: Argonne’s researchers and facilities playing a key role in the fight against COVID-19

2020.03.27 ANSTO’s Australian Synchrotron (Victoria), article and video: Helping in the fight against COVID-19

2020.03.25 PETRA III at DESY (Germany), article: Research team will X-ray coronavirus proteins

2020.03.23 Diamond Light Source (UK) releases its first animation explaining: SARS-CoV-2 Mpro Single Crystal Crystallography

2020.03.25 CERN Courrier (Switzerland) article about synchrotron research on SARS-CoV-2, written by Tessa Charles (accelerator physicist at the University of Melbourne currently based at CERN, completed her PhD at the Australian Synchrotron): Synchrotrons on the coronavirus frontline

2020.03.19 BESSY II at Helmholtz-Zentrum Berlin (Germany), research publication: Coronavirus SARS-CoV2: BESSY II data accelerate drug development

2020.03.19 BESSY II at Helmholtz-Zentrum Berlin (Germany), technique explanation webpage: Protein crystallography at BESSY II: A mighty tool for the search of anti-viral agents

2020.03.16 Diamond Light Source (UK), article on their “Coronavirus Science” website: Main protease structure and XChem fragment screen

2020.03.12. Elettra Sincrotrone (Italy), article on their website: New project to fight the spread of Coronavirus has been approved

2020.03.05. Advanced Photon Source (IL / USA), article on their website: APS Coronavirus Research in the Media Spotlight

2020.03.05. Advanced Photon Source (IL / USA), research publication: “Crystal structure of Nsp15 endoribonuclease NendoU from SARS-CoV-2,” bioRXiv preprint  DOI: 10.1101/2020.03.02.968388, Article on their website (source: Northwestern University): New Coronavirus Protein Reveals Drug Target

Facility Covid-19 research pages

The Canadian Light Source (Canada) has created a specific page highlighting their COVID-19 research: COVID-19 research at the Canadian Light Source

BESSY II at HZB (Germany) has set up a page where it shows their contributions to the research on SARS-CoV-2 , see here

DESY (Germany) has launched a new page dedicated to Corona Research: https://www.desy.de/news/corona_research/index_eng.html

Diamond Light Source (UK) has created a specific website “Coronavirus Science” with platforms for various audiences: scientific community, general public and the media: https://www.diamond.ac.uk/covid-19.html

ELETTRA (Italy) has launched a new page dedicated to COVID-19 research: https://www.elettra.eu/science/covid-19-research-at-elettra.html

The Photon Division of PSI (Switzerland) have collated many information linked to their institute on coronavirus-relevant research (recent publications, rapid access…): https://www.psi.ch/en/psd/covid-19

ALBA (Spain) has set up a dedicated area on their website for information related to COVID-19 (rapid access, publications etc): https://www.albasynchrotron.es/en/covid-19-information/

The ALS (CA/USA) has created a page listing all COVID-19 related research: https://als.lbl.gov/tag/covid-19/




Rapid access

Scientists can apply for rapid access at following facilities (only member facilities of Lightsources.org are referenced, the most recent published (or updated) call is mentioned first).

  • The National Synchrotron Light Source II (NSLS-II) in NY / USA is offering a streamlined and expedited rapid access proposal process for groups that require beam time for structural biology projects directly related to COVID-19. The Center for Biomolecular Structure team is supporting remote macromolecular crystallography experiments at Beamlines 17-ID-1 (AMX) and 17-ID-2 (FMX) in this research area. To submit a macromolecular crystallography proposal for COVID-19 related research, use the following form:
    https://surveys.external.bnl.gov/n/RapidAccessProposal.aspx
  • The Advanced Photon Source (APS) at Argonne National Laboratory in IL / USA  user program is operational to support:

·         Research on SARS-CoV-2 or other COVID-19-related research that addresses the current pandemic.

·         Critical, proprietary pharmaceutical research.

·         Mail-in/remote access work for any research involving low-risk samples and most medium-risk samples (as defined on the APS ESAF form).

·         Limited in situ research (set-up with one person, and ability to carry out majority of experiment safely remotely)
https://www.aps.anl.gov/Users-Information/About-Proposals/Apply-for-Time

PETRA III at DESY in Germany offers also Fast Track Access for Corona-related research:
https://photon-science.desy.de/users_area/fast_track_access_for_covid_19/index_eng.html

Australian Synchrotron at ANSTO makes its macromolecular crystallography beamlines available to structural biologists in response to the COVID-19 pandemic: https://www.ansto.gov.au/user-access

North American DOE lightsource facilities have created a platform to enable COVID-19 research. There you can find ressources and points of contact to request priority access:
Structural Biology Resources at DOE Light Sources

Elettra Sincrotrone Trieste in Italy opens to remote acces following beamlines: XRD1, XRD2, SISSI-BIO and MCX thanks to an CERIC-ERIC initiative:
https://www.ceric-eric.eu/2020/03/10/covid-19-fast-track-access/
http://www.elettra.eu/userarea/user-area.html

The Advanced Light Source (ALS) at LBNL in California / USA has capabilities relevant to COVID-19 and researchers can apply through their RAPIDD mechanism:
https://als.lbl.gov/apply-for-beamtime/

ALBA Synchrotron in Spain offers a COVID-19 RAPID ACCESS on all beamlines:
https://www.albasynchrotron.es/en/en/users/call-information

SOLARIS Synchrotron in Poland gives acces to its Cryo Electron Microscope thanks to an CERIC-ERIC initiative: https://www.ceric-eric.eu/2020/03/10/covid-19-fast-track-access/

Swiss Light Source and Swiss FEL at PSI in Switzerland offer priority access to combating COVID-19:
https://www.psi.ch/en/sls/scientific-highlights/priority-access-call-for-work-on-combating-covid-19

Diamond Light Source in the United Kingdom opened also a call for rapid access:
https://www.diamond.ac.uk/Users.html

Image: Electron density at the active site of the SARS-CoV-2 protease, revealing a fragment bound
Credit: Diamond Light Source

NSRRC Users honoured at MOE 2025 National Awards Ceremony

NSRRC Users honoured at MOE 2025 National Awards Ceremony

On March 23, the Ministry of Education (MOE) held the award ceremony for the 2025 National Chair Professorships, National Award for Distinguished Contribution to Industry-Academia Cooperation, and Academic Awards. Five NSRRC users were among the recipients.

Prof. Hsin-Lung Chen, Distinguished Chair in the Department of Chemical Engineering at Tsing Hua University (NTHU), received the National Chair Professorship in Engineering and Applied Sciences. A leading scholar in polymer physics, he has long contributed to theoretical development, textbook writing, and industry-academia collaboration. His research has been widely applied in critical materials and industrial technologies, enhancing the international impact of Taiwan’s materials research.

Prof. Bing-Joe Hwang, Chair Professor in the Department Chemical Engineering at the National Taiwan University of Science and Technology, founder and director of the Sustainable Electrochemical Energy Development Center, and NSRRC board member and adjunct scientist, received the National Award for Distinguished Contribution to Industry-Academic Cooperation in Engineering. He pioneered the “anode-free lithium battery,” developed high-energy-density and high-safety technologies, and promoted high-value hydrogen electrolysis, with extensive industrial applications and patents.

Two NSRRC users were awarded the Academic Award in Mathematics and Natural Sciences. Prof. Chen-Wei Liu, Chair Professor in the Department of Chemistry at National Dong Hwa University, is an international pioneer in metal cluster chemistry. His research combines fundamental innovation with practical application, offering forwarded-looking contributions to catalysis and carbon-reduction technologies. Prof. Ying-Hao Chu, Chair Professor and Department Chair of Materials Science and Engineering at NTHU, specializes in oxide heterostructures and flexible mica-based electronic components, with highly cited work that lays a critical foundation for next-generation electronic devices. In Engineering and Applied Sciences, Prof. Chih-Huang Lai, Chair Professor and Vice Dean of the Institute of Semiconductor at NTHU, was recognized for his research in spintronics and magnetic materials, including advanced memory devices and thin-film solar technologies, as well as Taiwan’s first 12-inch MRAM production line.

Read more on the NSRRC website

Optimization of 2D material-based devices

Optimization of 2D material-based devices

How to visualize electric fields in situ to boost the performance of tomorrow’s LEDs

2D materials are excellent candidates for light emission in LED-type components. Furthermore, combining several of these materials with different properties (metal, insulator, semiconductor) theoretically makes it possible to obtain complex components that combine these properties. To function, these components must be connected to electrodes. But where exactly should the electrical voltage be applied? 
To answer this question, a team from the Paris Institute of NanoSciences used the ANTARES beamline to probe operando the distribution of the electric field within a heterostructure composed of two semiconductors.

Two-dimensional (2D) materials, such as transition metal dichalcogenides (TMDs) (e.g., MoS₂, WSe₂, and their derivatives), exhibit strongly enhanced excitonic effects due to the robust Coulomb coupling between electron-hole pairs. This makes them outstanding candidates for light emission in devices such as LEDs. A second key advantage of this materials platform is the ability to assemble these materials without epitaxial constraints. In theory, this allows for the combination of materials with diverse properties—metals, insulators, and semiconductors with tunable bandgaps—to fabricate complex devices. The entire structure is ultimately connected to electrodes, which serve to inject charges or modulate the potential profile. However, a critical challenge remains: the voltage must be applied in the right location! In these structures, the energy landscape is influenced by edge effects, doping, flake thickness, defects, and above all interfaces. In this study, a team from INSP uses the ANTARES beamline to operando probe the electric field distribution within a heterostructure composed of two semiconductors.

In optoelectronic devices, electrodes are used to inject the current/energy necessary for device operation. In the context of LEDs, applying a bias is essential to inject holes into the valence band while electrons are resonantly injected into the conduction band. When these energy conservation rules are fulfilled, charges can be injected into the optically active semiconductor, enabling light emission. However, the turn-on voltage for an LED can be significantly larger than the material’s bandgap if an electric field is also applied to the intermediate material between the electrode and the optically active layer. This results in power efficiency losses, which must be mitigated. Therefore, the localization of the electric field is critical, and tools to measure the field distribution operando are essential.

Read more on the SOLEIL website

Smarter fungicides: Fighting infection while protecting soil health

Smarter fungicides: Fighting infection while protecting soil health

Copper nanoparticles could lead to less polluted soils in vineyards, according to a study published in Environmental Science: Nano. The researchers came to the ESRF’s ID21 to track how copper behaved in grapevines plants inoculated with a fungus.

Copper-based pesticides have been used around the world vineyards to keep fungal diseases at bay for more than a century in the form of Bordeaux mixture. Whilst it has proven to be extremely effective, copper is a metal and accumulates over time. Bordeaux mixture has a low affinity to plant leaves. When it rains, it washes it off the plants onto the soil, where it can harm earthworms, beneficial microbes and long-term soil health, which can lead to less productive soil in the long run.

Winemakers, particularly in the organic sector, where copper remains one of the few approved fungicides, face a difficult question: how can they protect their vines without poisoning their soils? With the aim of pushing more environmentally friendly practices, European regulators are increasingly limiting the amount of copper to be used in grapevines.

“We wanted to test whether copper nanoparticles (copper oxide) could be as reactive as the traditional sprays but using much less quantity”, explains Astrid Avellan, CNRS researcher and corresponding author of the publication.

Read more on the ESRF website

Image: Astrid Avellán preparing the samples in the lab at the ESRF’s ID21

Credit: D. Salvador

Blood pressure-lowering drug with a light switch

Blood pressure-lowering drug with a light switch

From off to on in fractions of a second – researchers at the Paul Scherrer Institute PSI have investigated a light-switchable drug for high blood pressure: They observed how the molecule transforms from one form to another and how this affects its effectiveness in the body. This could aid in the development of medications whose effects can be precisely controlled, within the body, using light. The study has now been published in the journal Angewandte Chemie International Edition.

Rendering a drug effective or ineffective in a flash at the appropriate location – this is the focus of research in photopharmacology. The goal is to develop drugs that can be switched on and off with light of a specific wavelength. Orally administered medications could then be selectively activated by irradiating only a specific part of the body with light; the medication would remain ineffective in the rest of the body – thus reducing side-effects. For example, a drug intended to lower blood pressure in the heart could then be activated only there; other organs with identical binding sites for the active ingredient would remain unaffected.

Researchers in the PSI Center for Life Sciences have now observed, at the molecular level, how a light-switchable drug interacts with its corresponding biological receptor. Most important, they have discovered why the drug changes its potency.

“Observing exactly what happens at such receptors when a drug is altered by light is an important step toward making light-switchable drugs a reality in the clinic,” says Jörg Standfuss, a laboratory head in the PSI Center for Life Sciences and co-author of the new study published in the journal Angewandte Chemie International Edition.

Read more on the PSI website

Image: Jörg Standfuss (left) and Quentin Bertrand are two of the researchers in the PSI Center for Life Sciences who now have found out, on the molecular level, why a light-controllable drug changes its potency.

Credit: © Paul Scherrer Institute PSI/Markus Fischer

Wet planets might evolve from dry, hydrogen-rich planets

Wet planets might evolve from dry, hydrogen-rich planets

Sub-Neptunes, or exoplanets 2–4 times Earth’s radius, are abundant in our galaxy. Models indicate that these exoplanets have rocky cores (the non-volatile interior) blanketed by envelopes of either hydrogen (dry gas dwarfs) or water (water worlds). 

In our own solar system, the water worlds of Uranus and Neptune orbit far from the sun, where temperatures are low enough for water to condense. This has led to the idea that water-rich planets form in the outer orbits of planetary systems, beyond what is known as the snow or ice line. They may then migrate inwards, to orbit closer to their star.

In recent years, however, large numbers of potentially water-rich exoplanets have been discovered in very close orbits. This is difficult to reconcile with the idea that such worlds can only form beyond the snow line.

The latest research by scientists from Arizona State University, The University of Chicago and the Open University of Israel suggests that water could be produced through chemical reactions at the boundary between a dry planet’s rocky core and hydrogen-rich atmosphere. This finding calls into question the idea that a planet’s composition is linked to where it formed. 

Researchers used the resources of the Advanced Photon Source (APS), a U.S. Department of Energy (DOE) Office of Science user facility at DOE’s Argonne National Laboratory. Their results were published in the journal Nature.

To explore the potential high pressure and temperature interactions between the hydrogen in the envelope and silicate in the core of dry planets at the core-envelope boundary, the team used the unique capabilities of the University of Chicago’s GeoSoilEnviroCARS beamline at 13-ID-D of the APS. This beamline’s high pressure, high temperature diamond anvil cell setup is designed to probe materials in-situ at extreme conditions to answer geochemical and geophysical questions across the pressure and temperature range of Earth and other planets. 

Read more on the APS website

Image: The high pressure, high temperature diamond anvil cell experiments suggest that reactions between dense hydrogen fluid and molten silicates on dry planets could generate substantial amounts of water. This hints at a potential way for dry, hydrogen-rich planets to evolve into watery worlds, challenging conventional planetary formation theory.

Diamond-developed acoustic levitator heads to space

Diamond-developed acoustic levitator heads to space

A technology that began as a simple, open-source acoustic levitator at Diamond will be used in a SpaceX experiment. 

The advanced system, known as SuperLev, has been selected for a programme of microgravity experiments that will see it tested in parabolic zero-gravity flights before progressing to longer-duration missions in space. Designed to operate autonomously with onboard imaging and intuitive control software, the compact levitator is being adapted to withstand the rigours of launch and sustained operation in orbit, marking a significant milestone for a technology originally developed to enhance synchrotron science.

In 2019, R&D specialist Dr Pete Docker from the Technical division along with scientists introduced to Diamond TinyLev, a compact, low-cost acoustic levitator built from off-the-shelf components. Designed to suspend droplets and small particles in mid-air using precisely controlled sound waves, the system enabled researchers to study samples without physical contact. This contact-free approach proved valuable for X-ray experiments, where containerless environments reduce contamination and allow samples to be held in the beam.

What began as a proof-of-principle device has since inspired the development of a next-generation platform known as SuperLev.

From lab bench innovation to global adoption

Building on the principles demonstrated at Diamond, SuperLev integrates an onboard high-resolution camera and intuitive, user-friendly software, allowing researchers to monitor and control levitated samples in real time. The system’s enhanced acoustic arrays provide greater stability and flexibility, making it suitable for a wide range of materials science and biological applications.

The impact has been rapid and far-reaching. SuperLev is now being utilised and further developed in 20 laboratories and institutions worldwide. Its modular design and accessibility reflect the same ethos that underpinned TinyLev: making advanced scientific tools more widely available.

Read more on Diamond website

A duo for BESSY III light source

A duo for BESSY III light source

Since 1 March 2026, Renske van der Veen and Andreas Jankowiak have formed the leadership team of BESSY III. Together, they will drive forward HZB’s central project: the planning and realisation of BESSY III light source in Berlin-Adlershof. Here, they talk about their motivation, the next steps, and why BESSY III is a a cross-generational project.

Dear Renske, dear Andreas, a new chapter for our huge BESSY III project is now beginning with you. What do you bring to the table?

Renske van der Veen: Energy and enthusiasm for the project and also for teamwork! I love working with lots of people to achieve something big. For me, BESSY III is a fantastic opportunity to put all this into practice, and I also bring the necessary pragmatism to the table.

Andreas Jankowiak: I bring 15 years of experience at HZB in various management positions and experience from different committees. For example, I have been chairing the machine advisory committee of Diamond II (successor to Diamond, UK) for six years. This gives me a sense of what is happening around us in this field and how things are developing there. I am also enthusiastic that we are a research centre with our own strong research profile, which benefits greatly from our large-scale facility BESSY. For me, this connection is an absolute added value.

Read more on the HZB website

Image: Renske van der Veen und Andreas Jankowiak take over the scientific and technical projectlead of BESSY III light source

Credit: © HZB / Florentine Krawatzek

New malaria vaccine shows promise in preclinical trials

New malaria vaccine shows promise in preclinical trials

International research team used CLS to map structure of human antibodies bound to their prototype vaccine.

Malaria is caused by a parasite that is spread to humans by infected mosquitoes. In 2024, almost 282 million people worldwide were infected and 610,000 died, according to the World Health Organization. Malaria is a leading cause of death in children under the age of five.

Using the Canadian Light Source (CLS) at the University of Saskatchewan, an international team involving researchers from Canada, the US, and the Netherlands have developed a novel vaccine that is showing considerable promise in preclinical trials.Video: New malaria vaccine shows promise in preclinical trials

“Our long-term goal is to eliminate malaria by designing a vaccine that is more effective than the ones currently on the market,” says lead author Danton Ivanochko, a researcher at the Hospital for Sick Children (SickKids) in Toronto.

When the researchers examined blood samples from people with naturally acquired immunity to malaria, they were able to identify which proteins on the parasite play the largest role in transmission.

Read more on the CLS website

Chemical shifts help track molecules breaking apart in real time

Chemical shifts help track molecules breaking apart in real time

Ultrafast X-ray photoelectron spectroscopy at European XFEL offers a new way to watch reactions, atom by atom.

When molecules fall apart, their electric charge doesn’t stay put—it rearranges as bonds stretch and break. An international team of scientists has now tracked these ultrafast changes in the small molecule fluoromethane (CH₃F). It was the first time that the Small Quantum Systems (SQS) instrument at European XFEL could deliver detailed insights into transient states during chemical reactions. These intermediate states, that only exist temporarily while the reaction is ongoing, are often the key drivers of chemistry and therefore crucial to understand. Over the long term, that kind of insight can support progress in areas such as atmospheric science (where sunlight-driven reactions and fragmentation pathways shape air chemistry), as well as the study of complex molecular systems including biomolecules and proteins, where local excitation and charge transfer can trigger structural change.

In the experiment, the researchers first triggered the reaction with an optical laser pulse. Next, they used the X-ray laser pulses that the European XFEL produces, to eject an electron from the core of either the fluorine or the carbon atom in the molecule. They measured the electron’s kinetic energy, which reveals how strongly it was bound inside the atom. That binding energy is extremely sensitive to the local electrical environment, producing so-called “chemical shifts” that act like a fingerprint of the charge distribution surrounding the atom from which the electron has been ejected. With an overall time resolution of about 35 femtoseconds (trillions of times shorter than the blink of an eye), the team could follow changes separately at two atomic sites, carbon and fluorine, inside the same molecule. The method is called time-resolved X-ray photoelectron spectroscopy (tr‑XPS).

“Core-level photoelectron spectroscopy tells us what is happening at a specific atom,” says Michael Meyer, lead scientist at the Small Quantum Systems (SQS) instrument at European XFEL. “By probing carbon and fluorine independently, we can see when different fragments appear and how the charge distribution evolves during dissociation. 

Read more on the European XFEL website

Image: Illustration of the pump–probe experiment on fluoromethane (CH₃F): Shortly after an ultrashort optical laser pulse (red) has ionized the molecule and triggered bond breaking, a femtosecond X-ray pulse (blue/white) ejects a core electron (green clouds) from the fluorine atom (green ball). By measuring the electron’s kinetic energy, the experiment tracks time-dependent ‘chemical shifts’ that reveal how the local electronic environment changes as the molecule dissociates – in this case the departure of a hydrogen atom (white ball).

Credit: Illustration: European XFEL

When carbon and nitrogen meet under pressure

When carbon and nitrogen meet under pressure

Three recent papers expand understanding of chemistry relevant to biology and industry

When it comes to the chemical elements, few are simultaneously as ubiquitous and necessary as carbon and nitrogen. They form the backbone of life, they enable many catalytic processes used in industry, they lie at the heart of many key materials in our everyday lives, and they make up over 78% of the composition of our atmosphere (almost all of that amount being nitrogen). Their chemistry has been widely studied for centuries, forming the foundation of organic chemistry and revealing entire libraries’ worth of reactions across inorganic chemistry. That chemistry forms the basis for common methods in mining, electroplating, pharmacology, and much more. But an international research team led by scientists at the Goethe University Frankfurt have shown that this familiar picture only accounts for a small fraction of what carbon and nitrogen can do—one just has to turn up the heat and the pressure. A series of studies published in the Journal of the American Chemical Society (JACS) and Angewandte Chemie International Edition reveal that under high pressure, carbon and nitrogen can simultaneously react with a variety of metals. The results could have a strong influence on future functional materials.

Carbon and nitrogen from very stable compounds. Molecular nitrogen N2 in the atmosphere, in particular, forms triple bonds that require a large amount of energy to break, and solid elemental carbon can be arranged to make diamonds, among the hardest and most corrosion-resistant compounds known. While carbon and nitrogen do react at ambient pressure forming cyanogen (CN)2  – a colorless toxic gas — their behavior can completely change under high pressure.  

However, the studies ley by scientists from the Goethe University Frankfurt revealed new pathways to make novel carbon-nitrogen anions through the use of extreme pressures. By pressing the reacting substances between two diamonds—in a device called a diamond anvil cell—while simultaneously heating the reactants at high precision using lasers, the team could get the nitrogen and carbon to bond together forming negatively charged ions, which are stabilized in novel compounds with positively-charged metallic ions.

Image: Using diamond anvil cells and laser heating, the research team has been able to produce new kinds of chemical reactions with ultra-stable carbon and nitrogen atoms, allowing them to form novel compounds with metals such as bismuth, cadmium, calcium, and europium.

Credit: Goethe University Frankfurt

Read more on DESY website

The study of Gallo-Roman curse tablets discovered in Orléans continues at the PSICHÉ beamline

The study of Gallo-Roman curse tablets discovered in Orléans continues at the PSICHÉ beamline

After conducting a first series of highly conclusive test measurements in October 2024 on the PSICHE beamline, two archaeologists from the Archaeology Department of the City of Orléans returned in December 2025 with the aim of accessing the texts inscribed on 17 Gallo-Roman curse tablets. Their five intense days of X-ray microtomography on PSICHE have already yielded a wealth of results.

In Orléans, as part of the redevelopment of the former Porte Madeleine hospital, a previously unknown Gallo-Roman necropolis was uncovered thanks to two successive archaeological excavation campaigns carried out between 2022 and 2025. During these excavations, 23 Gallo-Roman lead curse tablets (defixiones, from the Latin defixio, meaning curse or spell) were discovered in the graves, some folded in half, others completely rolled up on themselves.

In order to access the texts engraved on these fragile and precious objects, a few rare tablets were able to be opened, with great expertise and care and following a stabilisation treatment, by a conservator-restorer. However, in most cases, examination of the tablets showed that opening them manually would risk damaging them and, with them, the unique texts they bear.

Yet, using X-ray microtomography, the PSICHÉ beamline team succeeded in 2023 in virtually unrolling a 1,700-year-old lead talisman, revealing an engraved text in the Mandaean language that could then be deciphered.

Read more on the SOLEIL website

Image: At the PSICHÉ beamline workstation, meticulous preparation of the X-ray microtomography scan of a curse tablet

Credit: © SAVO, 2025

Synchrotron light reveals how a plant enzyme reshapes sugars to drive essential biological reactions

Synchrotron light reveals how a plant enzyme reshapes sugars to drive essential biological reactions

Using XALOC beamline at ALBA, researchers from the Institute of Biocomputation and Physics of Complex Systems (BIFI), at the University of Zaragoza, have discovered an unexpected way in which a plant enzyme activates sugars during a fundamental biochemical reaction. The findings, published in Nature Communications, challenge long-standing assumptions about how glycosyltransferase enzymes work and provide new foundations for biotechnological innovation.

Sugar-modifying enzymes play a central role in life. They control how sugars are attached to proteins and other molecules, a process that influences cell communication, development, immunity and responses to stress. In plants, these reactions are essential for building cell walls and regulating growth, while in humans similar enzymes are linked to disease processes and the effectiveness of therapeutic antibodies. Understanding exactly how these enzymes work at the molecular level is crucial not only for basic biology, but also for improving biomedicine, agriculture and industrial biotechnology.

The study of this group from BIFI at the University of Zaragoza focuses on FUT11, a fucosyltransferase enzyme from the model plant Arabidopsis thaliana. Glycosyltransferases such as FUT11 catalyse the formation of glycosidic bonds by transferring a sugar from a donor molecule to an acceptor. Traditionally, scientists assumed that during this reaction the acceptor sugar remained largely passive, maintaining a stable shape while the enzyme activated the donor. Using high-resolution structural data collected at the XALOC beamline – one of the ALBA’s instruments for X-ray crystallography-, the researchers were able to visualise FUT11 bound to its substrates and discovered a very different picture.

The crystal structures collected at ALBA (BL13 XALOC) provided the structural framework for mechanistic interpretation, and the accompanying atomistic simulations indicated that FUT11 actively promotes a transient distortion (puckering) of the acceptor sugar ring away from its most stable chair conformation. In these simulations, the catalytic base—Glu158—acts not only as the proton abstractor but also as a conformational effector: its interactions bias the innermost GlcNAc into a reactive, puckered state that better aligns the acceptor hydroxyl for nucleophilic attack and efficient bond formation.

Read more on the ALBA website

Image: Researchers Víctor Taleb, María Bort, Ramón Hurtado from BIFI

Credit: Unizar

Cheaper, greener steel for the automotive industry

Cheaper, greener steel for the automotive industry

Finnish researchers develop new composition, manufacturing process for producing stronger steel

Automakers today use a special type of steel (called Advanced High-Strength Steel, or AHSS) in components critical to driver and passenger safety, such as safety cages and bumpers. These parts of the car are designed to absorb collision forces so that less impact is transferred to occupants.

Researchers in Finland have developed not only a new composition for this type of steel but also a new manufacturing process that produces a stronger steel while also making it cheaper and more environmentally friendly. Their findings are published in the journal Materials & Design.

“We wanted to know: can we make steels that are two or three times stronger than current formulations, so we can reduce the amount of steel required and lower the overall weight of a vehicle?”  says Roohallah Aliabad, a researcher at the Microstructure and Mechanisms research group (Centre for Advanced Steels Research) at the University of Oulu. “A byproduct of this research is reducing greenhouse gas emissions. When you reduce the weight of cars, you are indirectly contributing to that goal.”

Aliabad and his colleagues are investigating compositions and processing routes that use manganese as an alloying element. Manganese is significantly less expensive than chromium and nickel, which are traditionally used in steel alloys. The team found that, by tailoring the microstructure of their steel, they could create an ultra strong, non-uniform microstructure (controlled heterogeneity) that contains two types of austenite, a form of iron.

Read more on the CLS website

Image: Roohalah Aliabad, Centre for Advanced Steels Research, University of Oulu (Finland)

Faster, smarter X‑ray spectroscopy with AI

Faster, smarter X‑ray spectroscopy with AI

Artificial intelligence makes X‑ray spectroscopy five times faster, smarter and less prone to human error

Argonne team’s AI-driven method takes over the manual parts of advanced X-ray spectroscopy, reducing human error and boosting experimental speed.#

Artificial intelligence (AI) is transforming nearly every branch of science. And researchers at the U.S. Department of Energy’s (DOE) Argonne National Laboratory are helping lead the way.

“There is a lot of hype around AI today in the media,” said Mathew Cherukara, a computational scientist and group leader at Argonne’s Advanced Photon Source (APS), a DOE Office of Science user facility. ​“Yet there is no question that AI can help researchers at APS and other light sources make breakthroughs in advanced chemical processes critical to American industry.”

As proof, the Argonne team has developed an AI-guided method that dramatically speeds up a widely used X-ray technique known as X-ray absorption near-edge structure (XANES) spectroscopy. It does so with far less risk of human error or damage to the sample from the X-ray beams.

This powerful analytical tool reveals the hidden chemistry inside materials important to modern life, such as batteries, catalysts and materials through which electricity flows without resistance. The team’s AI approach cuts the number of measurements previously needed by as much as 80%, with no loss of accuracy. The result is a dramatic shortening of data acquisition duration, allowing researchers to capture fast chemical changes in real time.

“Yet there is no question that AI can help researchers at APS and other light sources make breakthroughs in advanced chemical processes critical to American industry.” – Mathew Cherukara, computational scientist and group leader at Argonne’s Advanced Photon Source

Here’s how XANES works: Scientists shine X-ray beams with increasing energy onto a material. Each X-ray beam is a tiny packet of energy. When the energy is high enough to knock a tightly bound electron out of an atom, the material suddenly absorbs more X-rays. This sharp jump in absorption is called the absorption edge.

By tracking how X-ray absorption changes before, during and after this edge, researchers can watch the chemistry of a specific element unfold within a material, from how a metallic catalyst reacts with other chemicals to how the charge state of a battery element changes during cycling.

“XANES is incredibly powerful, but until now, scientists had to make dozens or even hundreds of choices about where to measure and how long to measure at each X-ray energy level,” said Shelly Kelly, an APS physicist and group leader.

Image: Artistic rendering shows new AI-guided approach capturing absorption edge from atomic structure of material analyzed by XANES at a light source.

Credit: Argonne National Laboratory

Read more on Argonne website

Bringing cryo-correlative hard X-ray microscopy to life science

Bringing cryo-correlative hard X-ray microscopy to life science

Scientists led by the ESRF, UGA and INSERM have developed cryo-correlative nano-imaging, a new technique that combines lab cryo-fluorescence microscopy, cryo X-ray fluorescence nanoimaging and phase-contrast nano-tomography on ID16A. The results are published in ACS Nano.

Biologists have long wanted to answer a deceptively simple question: what are the structures we see inside cells actually made of? Visible light fluorescence microscopy shows where organelles are, but not their chemical composition. Hard X-rays can map the chemistry but do not necessarily see the organelles. Cryo-correlative nanoprobe work remains rare, particularly for 3D elemental imaging of whole frozen cells.

A new study at ID16A beamline of the ESRF offers a practical solution. An international team has developed an integrated cryogenic workflow that links laboratory cryo-fluorescence microscopy to targeted cryo X-ray fluorescence (XRF) nano-imaging and phase-contrast nano-tomography.

With this new method, they have tracked therapeutic nanoparticles from the European ScanNtreat project as they moved through cancer cells, showing both where the particles went and what happened to them.

The first author of the publication, Dmitry Karpov, former ESRF scientist and now researcher at the Université Grenoble Alpes, explains how this new development can lead to applications: “This is an example of what the ESRF aims to do: to turn cutting-edge instrumentation into discoveries with direct impact on people’s lives, in this case for medicine and life sciences”.

Read more on the ESRF website

New JUNGFRAU detector in action for MX at Diamond

New JUNGFRAU detector in action for MX at Diamond

As part of the BBSRC ALERT funding scheme, Diamond recently secured a £1.3M award for a state-of-the-art JUNGFRAU 9M detector to support Diamond’s Microfocus Macromolecular Crystallography beamline I24. This new generation of detector will facilitate a leap forward in time-resolved structural biology research for Diamond’s users. The detector will allow access to much faster timescales – as fast as microseconds – than was previously impossible with the existing detectors in use.

The detector has now been installed at beamline I24 and the first ‘real-world’ data collected. The quality of the data recorded is excellent and even ahead of upcoming upgrades to the beamline, excellent data could be collected at 1 and 2 kHz.

The Jungfrau detector is an exciting addition to the beamline. The high quality of the first data collected are extremely encouraging and illustrate the gains the detector will provide for fast experiments at I24. Operation of the detector was made possible by multiple teams including designers, detector and software scientists, technicians, and beamline staff working together to get the JF9M up and running in a very tight timeframe.

Robin Owen, I24 Principal Beamline Scientist

The new detector brings challenges, not least the huge volume of data that can be generated. This will be addressed in part by high power on-beamline processing using NVIDIA GH200 Grace Hopper Superchip nodes. The GH200 are powerful CPU-GPU hybrid machines that are powerful enough to both reconstruct the 45 GB/s Jungfrau9M images, crystallographically process, and assess them for data quality in real-time.

Read more on the Diamond website

Image: Jungfrau 9M detector in-situ at I24 with a section of an exemplar diffraction image collected at 1 kHz from a human deacetylase and resulting electron density obtained from a single crystal at 100 K